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Dr. Mike Kaszuba

Malvern Panalytical

Mike has a PhD from The Polytechnic of Wales where he studied the physical biochemistry of liposomes using Nuclear Magnetic Resonance (NMR) techniques.  He followed this with Postdoctoral research into liposomal drug delivery systems at the University of Manchester.  

In 1996 Mike joined Malvern Panalytical as a Product Technical Specialist for the Zetasizer range of instruments. In 2010 Mike was appointed Technical Support Manager responsible for the Product Technical Specialists based in the UK. The PTS group provide technical and application support for end users of the various products Malvern Panalytical manufacture.  

Presentation:

Nanoparticle Size Characterisation Using Dynamic Light Scattering

Dynamic light scattering (DLS) is a non-invasive technique for measuring nanoparticle dispersions and macromolecular solutions. The technique measures the time-dependent fluctuations in the intensity of scattered light arising from a particle dispersion or molecular solution. These intensity fluctuations occur because of the random movement of the particles or molecule undergoing Brownian motion. Analysis of these intensity fluctuations using auto correlation determines the translational diffusion coefficients (D) and, subsequently, the hydrodynamic size (DH) using the Stokes–Einstein relationship. 

This lecture will discuss the different optical configurations available, how data is captured and processed during a measurement and analysed to obtain size information, the accuracy and precision expected from the technique, experimental considerations such as size and concentration ranges, and how to interpret the data and results obtained.  

The talk will also discuss the use of Multi-Angle Dynamic Light Scattering (MADLS®) for the measurement of nanoparticle concentration and results from different sample types will be presented.  

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